p53 anticorps (AA 1-100)

N° du produit ABIN6149405

Détail du produit anti-p53 anticorps

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Épitope: AA 1-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Séquence: EPPEAGSEYT TIHYKYMCNS SCMGGMNRRP ILTIITLEDS SGNLLGRDSF EVRVCACPGR DRRTEEENFR KKEVLCPELP PGSAKRALPT CTSASPPQKK KPLDGEYFTL KIRGRKRFEM FRELNEALEL KDAHATEESG DSRAHSSYLK TKKGQSTSRH KKTMVKKVGP DSD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 (NP_000537.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:3000 - 1:6000,IHC,1:50 - 1:200,IP,1:20 - 1:50

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-p53 (ABIN6149405)

Huang, Cui, Chen, Yang, Lian, Liu, Su, Liu, Wang, Hu, Ouyang, Li, Lu: "NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma." dans: Oncotarget, Vol. 9, Issue 12, pp. 10483-10496, (2018) (PubMed).

Huang, Zhou, He, Ke, Wen, Zou, Chen: "Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition." dans: Scientific reports, Vol. 6, pp. 38072, (2018) (PubMed).

Zhang, Cui, Wang, Zhao, Hou, Zeng, Zhang, Yu, Zhao, Nie, Chen, Wang, Liu: "Autophagy regulates high concentrations of iodide-induced apoptosis in SH-SY5Y cells." dans: Toxicology letters, Vol. 284, pp. 129-135, (2018) (PubMed).

Meng, Song, Wang, Li, Liu, Cui: "Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231." dans: Oncology reports, Vol. 37, Issue 2, pp. 841-848, (2017) (PubMed).

Cai, Huang, Luo, Yang, Zhang, Liu, Lin, Xie, Wang: "Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine." dans: Cell death & disease, Vol. 7, pp. e2161, (2016) (PubMed).

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: TP53 (TP53 Produits)

Synonymes: anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L

Sujet: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).,BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,Warburg Effect,Neuroscience,Neurodegenerative Diseases,TP53

Poids moléculaire: 43 kDa

ID gène: 7157

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg