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ANO1 anticorps (AA 2-101) (Biotin)

ANO1 Reactivité: Humain IF, FACS, IHC Hôte: Souris Monoclonal DG1-1484 Biotin
N° du produit ABIN6173035
  • Antigène Voir toutes ANO1 Anticorps
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Épitope
    • 17
    • 15
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-101
    Reactivité
    • 127
    • 31
    • 29
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 82
    • 49
    Souris
    Clonalité
    • 68
    • 63
    Monoclonal
    Conjugué
    • 58
    • 12
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ANO1 est conjugé à/à la Biotin
    Application
    • 63
    • 51
    • 42
    • 36
    • 35
    • 20
    • 18
    • 13
    • 13
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Fonction
    Mouse Monoclonal anti-DOG-1 / TMEM16A (DG1/1484), Biotin Conjugate
    Attributs du produit
    Expression of DOG-1 protein is elevated in gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4 % vs. 94.7 %. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogène
    Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
    Clone
    DG1-1484
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product ANO1 Anticorps primaire
  • Indications d'application
    Immunohistology (formalin) 0.5-1 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user
    Commentaires

    Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Antigène
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Autre désignation
    DOG-1 / TMEM16A (ANO1 Produits)
    Synonymes
    anticorps DOG1, anticorps ORAOV2, anticorps TAOS2, anticorps TMEM16A, anticorps Tmem16a, anticorps anoctamin 1, anticorps anoctamin 1, calcium activated chloride channel, anticorps Ano1, anticorps ANO1
    Sujet
    Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A
    Poids moléculaire
    ~114 kDa
    ID gène
    55107, 503074
    UniProt
    Q5XXA6
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