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INPP5D anticorps (AA 959-1188)

INPP5D Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6213625
  • Antigène Voir toutes INPP5D Anticorps
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    Épitope
    • 20
    • 19
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 959-1188
    Reactivité
    • 86
    • 61
    • 37
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 82
    • 5
    Lapin
    Clonalité
    • 70
    • 17
    Polyclonal
    Conjugué
    • 34
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp INPP5D est non-conjugé
    Application
    • 60
    • 21
    • 18
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    SPPTPPGQPP ISPKKFLPST ANRGLPPRTQ ESRPSDLGKN AGDTLPQEDL PLTKPEMFEN PLYGSLSSFP KPAPRKDQES PKMPRKEPPP CPEPGILSPS IVLTKAQEAD RGEGPGKQVP APRLRSFTCS SSAEGRAAGG DKSQGKPKTP VSSQAPVPAK RPIKPSRSEI NQQTPPTPTP RPPLPVKSPA VLHLQHSKGR DYRDNTELPH HGKHRPEEGP PGPLGRTAMQ
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 959-1188 of human SHIP1 (NP_005532.2).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    Autre désignation
    INPP5D (INPP5D Produits)
    Synonymes
    anticorps INPP5D, anticorps 256.t00004, anticorps 13.t00027, anticorps ship, anticorps ship1, anticorps AI323613, anticorps SHIP, anticorps SHIP-1, anticorps SHIP1, anticorps s-SHIP, anticorps SIP-145, anticorps hp51CN, anticorps inositol polyphosphate-5-phosphatase D, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, anticorps inositol polyphosphate 5-phosphatase, anticorps inositol polyphosphate-5-phosphatase D L homeolog, anticorps INPP5D, anticorps LOC100446045, anticorps inpp5d, anticorps EHI_159880, anticorps EHI_153490, anticorps inpp5d.L, anticorps LOC100380693, anticorps Inpp5d
    Sujet
    This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.,INPP5D,SHIP,SHIP-1,SHIP1,SIP-145,hp51CN,p150Ship,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,INPP5D
    Poids moléculaire
    109 kDa/133 kDa
    ID gène
    3635
    UniProt
    Q92835
    Pathways
    TCR Signaling, BCR Signaling, L'effet Warburg
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