RAPGEF2 anticorps (C-Term)

N° du produit ABIN6243297

Détail du produit anti-RAPGEF2 anticorps

Antigène: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Épitope: AA 1464-1498, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RAPGEF2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1464-1498 amino acids from the C-terminal region of human RAPGEF2.

Clone: RB52925

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RAPGEF2

Antigène: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Autre désignation: RAPGEF2 (RAPGEF2 Produits)

Synonymes: anticorps MGC83978, anticorps RAPGEF2, anticorps fa11h07, anticorps wu:fa11h07, anticorps CNrasGEF, anticorps NRAPGEP, anticorps PDZ-GEF1, anticorps PDZGEF1, anticorps RA-GEF, anticorps Rap-GEP, anticorps nRap GEP, anticorps 5830453M24Rik, anticorps CNRasGEF, anticorps Pdzgef1, anticorps RA-GEF-1, anticorps mKIAA0313, anticorps nRapGEP, anticorps Rap guanine nucleotide exchange factor 2, anticorps Rap guanine nucleotide exchange factor 2 L homeolog, anticorps Rap guanine nucleotide exchange factor (GEF) 2, anticorps RAPGEF2, anticorps rapgef2.L, anticorps rapgef2, anticorps Rapgef2

Sujet: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:< a href="http://www.uniprot.org/citations/23800469" target="_blank">23800469, PubMed:< a href="http://www.uniprot.org/citations/10801446" target="_blank">10801446) or not (PubMed:< a href="http://www.uniprot.org/citations/10608844" target="_blank">10608844, PubMed:< a href="http://www.uniprot.org/citations/10548487" target="_blank">10548487, PubMed:< a href="http://www.uniprot.org/citations/11359771" target="_blank">11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP- induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain- derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.

Poids moléculaire: 167417

UniProt: Q9Y4G8

Pathways: Neurotrophin Signaling Pathway