ATF6 anticorps (Internal Region)
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- Antigène Voir toutes ATF6 Anticorps
- ATF6 (Activating Transcription Factor 6 (ATF6))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATF6 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- ATF6 Antibody detects endogenous levels of total ATF6.
- Homologie
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ATF6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ATF6 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway." dans: Molecular medicine reports, Vol. 16, Issue 2, pp. 1493-1501, (2018) (PubMed).
: "Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis." dans: Life sciences, Vol. 203, pp. 291-304, (2018) (PubMed).
: "SWNHs (Single-Wall Carbon Nanohorns) Supervises Endoplasmic Reticulum (ER) Stress in Hepatocellular Carcinoma." dans: Journal of nanoscience and nanotechnology, Vol. 18, Issue 10, pp. 6740-6745, (2018) (PubMed).
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GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway." dans: Molecular medicine reports, Vol. 16, Issue 2, pp. 1493-1501, (2018) (PubMed).
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- Antigène
- ATF6 (Activating Transcription Factor 6 (ATF6))
- Autre désignation
- ATF6 (ATF6 Produits)
- Synonymes
- anticorps ATF-6-like, anticorps GB16435, anticorps ATF6, anticorps Atf6, anticorps ATF6A, anticorps 9130025P16Rik, anticorps 9630036G24, anticorps AA789574, anticorps Atf6alpha, anticorps ESTM49, anticorps activating transcription factor 6, anticorps uncharacterized LOC412432, anticorps activating transcription factor 6 S homeolog, anticorps cyclic AMP-dependent transcription factor ATF-6 alpha, anticorps ATF6, anticorps LOC412432, anticorps atf6.S, anticorps LOC100122162, anticorps Atf6
- Sujet
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Description: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Gene: ATF6
- Poids moléculaire
- 75kDa
- ID gène
- 22926
- UniProt
- P18850
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
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