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NF-kB p65 anticorps (pSer536)

NFkBP65 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, IP, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6255402
  • Antigène Voir toutes NF-kB p65 (NFkBP65) Anticorps
    NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))
    Épitope
    • 44
    • 31
    • 29
    • 28
    • 28
    • 25
    • 23
    • 23
    • 20
    • 17
    • 16
    • 15
    • 14
    • 11
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    • 5
    • 5
    • 5
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    • 4
    • 4
    • 4
    • 3
    • 3
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    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pSer536
    Reactivité
    • 540
    • 373
    • 301
    • 41
    • 38
    • 29
    • 24
    • 22
    • 18
    • 17
    • 14
    • 11
    • 5
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 491
    • 53
    • 4
    • 2
    • 1
    Lapin
    Clonalité
    • 457
    • 93
    Polyclonal
    Conjugué
    • 295
    • 30
    • 23
    • 19
    • 18
    • 17
    • 17
    • 17
    • 17
    • 17
    • 16
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 2
    • 2
    • 1
    Cet anticorp NF-kB p65 est non-conjugé
    Application
    • 427
    • 202
    • 134
    • 118
    • 112
    • 104
    • 92
    • 77
    • 75
    • 28
    • 25
    • 9
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificité
    Phospho-NF- kappaB p65 (Ser536) Antibody detects endogenous levels of NF- kappaB p65 only when phosphorylated at Serine 536
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human NF- kappaB p65 around the phosphorylation site of Serine 536
    Isotype
    IgG
    Top Product
    Discover our top product NFkBP65 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:500 IP 1:100-1:500 IF 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, sodium azide and glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, (2018) (PubMed).

    Huang, Zhang, Hou, Wang, Liu, Zhang, Chen, Zhu: "LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway." dans: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 194, (2018) (PubMed).

    Ding, Shen, Li, Jiang, Shen: "Therapeutic mild hypothermia improves early outcomes in rats subjected to severe sepsis." dans: Life sciences, Vol. 199, pp. 1-9, (2018) (PubMed).

    Wu, Zhu, Zhang, Yin, Kang, Cao, Tian, Lu, Liu: "EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer." dans: Molecular medicine reports, Vol. 17, Issue 6, pp. 7875-7885, (2018) (PubMed).

    Li, Zhao, Lin, Gong, An: "TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling." dans: Cell biology international, (2018) (PubMed).

    Zhu, Xu, Lv, He, Ye, Wang, Hu: "miR-199b-5p Regulates Immune-Mediated Allograft Rejection after Lung Transplantation Through the GSK3β and NF-κB Pathways." dans: Inflammation, Vol. 41, Issue 4, pp. 1524-1535, (2018) (PubMed).

    Wu, Gu, Mei, Xu, Jing, Yao, Chen, Yang, Chen, Yang, Qi, Hu, Wüthrich, Mei: "Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation." dans: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 31, Issue 11, pp. 1826-1834, (2017) (PubMed).

    Zhou, Lu, Chen, Ge, Chen, Xu, Shi, Dai, Li, Ju, Cao, Qin, Chen, Teng, Jiang: "AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice." dans: Scientific reports, Vol. 7, pp. 43245, (2017) (PubMed).

    Zeng, Li, Chen, Lv, Liu, Ran, Sun, Bieerkehazhi, Liu, Li, Lai, Watibieke, Dawulietihan, Li, Li: "Survivin activates NF‑κB p65 via the IKKβ promoter in esophageal squamous cell carcinoma." dans: Molecular medicine reports, Vol. 13, Issue 2, pp. 1869-80, (2016) (PubMed).

    Jiang, Zheng, Zhang, Yue, Liu, Ma, Yang, Wen: "Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages." dans: American journal of translational research, Vol. 8, Issue 11, pp. 4778-4790, (2016) (PubMed).

    Yang, Zheng, Zhang, He, Zhang, Ma, Zhang, Wu, Wen: "miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells." dans: Biochimica et biophysica acta, Vol. 1852, Issue 7, pp. 1477-89, (2015) (PubMed).

  • Antigène
    NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))
    Autre désignation
    NF kappaB p65 (NFkBP65 Produits)
    Synonymes
    anticorps C-Rel, anticorps NFKB3, anticorps p65, anticorps NFkB, anticorps c-rel, anticorps zgc:100833, anticorps Xrel2, anticorps Xrel3, anticorps rel, anticorps rel-A, anticorps rel2, anticorps rel3, anticorps v-rel, anticorps xrel, anticorps REL proto-oncogene, NF-kB subunit, anticorps RELA proto-oncogene, NF-kB subunit, anticorps v-rel reticuloendotheliosis viral oncogene homolog A (avian), anticorps v-rel avian reticuloendotheliosis viral oncogene homolog, anticorps v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog, anticorps REL, anticorps RELA, anticorps Rela, anticorps Rel, anticorps rel, anticorps rel.L
    Sujet

    Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).

    Gene: RELA

    Poids moléculaire
    65kDa
    ID gène
    5970
    UniProt
    Q04206
    Pathways
    Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades, S100 Proteins
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