MAP2K4 anticorps (pSer80)
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- Antigène Voir toutes MAP2K4 Anticorps
- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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Épitope
- pSer80
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MAP2K4 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- Phospho-MEK4/MKK4 (Ser80) Antibody detects endogenous levels of MEK4/MKK4 only when phosphorylated at Serine 80.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human SEK1/MKK4 around the phosphorylation site of Ser80.
- Isotype
- IgG
- Top Product
- Discover our top product MAP2K4 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
- Autre désignation
- MAP2K4 (MAP2K4 Produits)
- Synonymes
- anticorps JNKK, anticorps JNKK1, anticorps MAPKK4, anticorps MEK4, anticorps MKK4, anticorps PRKMK4, anticorps SAPKK-1, anticorps SAPKK1, anticorps SEK1, anticorps SERK1, anticorps SKK1, anticorps Sek1, anticorps Serk1, anticorps MKK4A-l, anticorps map2k4, anticorps zgc:136500, anticorps jnkk, anticorps mek4, anticorps mkk4, anticorps sek1, anticorps jnkk1, anticorps serk1, anticorps xmek2, anticorps mapkk4, anticorps prkmk4, anticorps 142758_at, anticorps CG9738, anticorps CT27508, anticorps D-MKK4, anticorps DMKK4, anticorps Dmel\\CG9738, anticorps JNKK2, anticorps Mpk4, anticorps SEK1/MKK4, anticorps dMKK4, anticorps dMkk4, anticorps hep, anticorps ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, anticorps ATMEK4, anticorps ATMKK4, anticorps F19C24.26, anticorps F19C24_26, anticorps MAP KINASE KINASE 4, anticorps mitogen-activated protein kinase kinase 4, anticorps MKK4B, anticorps zgc:194486, anticorps mitogen-activated protein kinase kinase 4, anticorps mitogen-activated protein kinase kinase 4a, anticorps MAP kinase kinase 4, anticorps mitogen activated protein kinase kinase 4, anticorps mitogen-activated protein kinase kinase 4b, anticorps MAP2K4, anticorps Map2k4, anticorps map2k4a, anticorps map2k4, anticorps Mkk4, anticorps MKK4, anticorps map2k4b
- Sujet
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Description: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Gene: MAP2K4
- Poids moléculaire
- 44kDa
- ID gène
- 6416
- UniProt
- P45985
- Pathways
- Signalisation MAPK, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
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