KIT anticorps (Mast/stem Cell Growth Factor Receptor) (pTyr721)

Details for Product anti-KIT Antibody No. ABIN6256004
Antigène
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • KIT
  • C-KIT
  • kit
  • receptor
  • sparse
  • Xkl-1
  • kit-a
  • kit-b
  • kl1-A
  • krk1
  • pbt
  • scfr
  • KIT proto-oncogene receptor tyrosine kinase
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
  • KIT proto-oncogene receptor tyrosine kinase S homeolog
  • KIT
  • Kit
  • kita
  • kit
  • kit.S
Épitope
pTyr721
69
67
65
65
51
46
34
33
32
32
26
25
23
20
18
18
18
18
18
18
17
17
17
17
17
17
17
17
17
17
17
15
15
15
15
15
12
11
10
10
10
9
9
9
9
9
9
9
9
8
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
6
5
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
1322
464
169
45
44
38
25
19
14
5
4
4
4
3
2
1
1
1
Hôte
Lapin
1049
359
161
14
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp KIT est non-conjugé
146
133
127
109
86
76
21
16
15
14
14
14
8
8
8
8
8
8
6
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
2
2
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
673
623
441
347
210
150
116
105
70
68
55
28
18
13
11
10
3
2
2
2
1
1
1
Options
Immunogène A synthesized peptide derived from human c-Kit around the phosphorylation site of Tyrosine 721
Isotype IgG
Specificité Phospho-c-Kit (Tyr721) Antibody detects endogenous levels of c-Kit only when phosphorylated at Tyrosine 721
 Réactivité croisée Humain, Souris, Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Plasmids, Primers & others Plasmids, Primers & others KIT products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation c-Kit (KIT Antibody Extrait)
Sujet

Description: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Gene: KIT

Poids moléculaire 120,145kDa
ID gène 3815
UniProt P10721
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB 1:500-1:2000 IHC 1:100-1:500, IF/ICC 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months
Images (Fournisseur)
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilize...
Western Blotting (WB) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) Western blot analysis of c-Kit phosphorylation expression in HeLa whole cell lysates,...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Human heart tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Human heart tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Human liver cancer tissue sections by IHC-P. The tissue...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Human liver cancer tissue sections by IHC-P. The tissue...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Human lung cancer tissue sections by IHC-P. The tissue ...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Mouse spleen tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Rat liver tissue sections by IHC-P. The tissue was form...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Rat ganstric tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody (ABIN6256004) ABIN6267365 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Avez-vous cherché autre chose?