SNAIL anticorps (pSer246)

N° du produit ABIN6256209

Détail du produit anti-SNAIL anticorps

Antigène: SNAIL (SNAI1)

Épitope: pSer246

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-SNAIL (Ser246) Antibody detects endogenous levels of SNAIL only when phosphorylated at Serine 246.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human SNAIL around the phosphorylation site of Ser246.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-SNAIL (ABIN6256209)

Bychkov, Kirichenko, Shulepko, Mikhaylova, Kirpichnikov, Lyukmanova: "Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis." dans: Biomedicines, Vol. 9, Issue 10, (2021) (PubMed).

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI1 (SNAI1 Produits)

Synonymes: anticorps SLUGH2, anticorps SNA, anticorps SNAH, anticorps SNAIL, anticorps SNAIL1, anticorps dJ710H13.1, anticorps AI194338, anticorps Sna, anticorps Sna1, anticorps Snail, anticorps Snail1, anticorps SNAI1, anticorps BG:DS01845.1, anticorps CG3956, anticorps Dmel\\CG3956, anticorps Sco, anticorps br28, anticorps br29, anticorps l(2)35Db, anticorps l(2)br28, anticorps l(2)br29, anticorps l(3)br28, anticorps l35Db, anticorps sn, anticorps Xsnail, anticorps sna, anticorps snail1, anticorps xSna, anticorps Snai, anticorps sna2, anticorps snail2, anticorps cb643, anticorps sna-1, anticorps sna1, anticorps snai1, anticorps snail1a, anticorps zgc:109820, anticorps snail family transcriptional repressor 1, anticorps snail family zinc finger 1, anticorps snail homolog 1 (Drosophila), anticorps snail, anticorps zinc-finger transcription factor Snail, anticorps snail family zinc finger 1 S homeolog, anticorps protein escargot, anticorps transcription factor protein, anticorps snail zinc finger protein, anticorps snail family zinc finger 1b, anticorps snail family zinc finger 1a, anticorps SNAI1, anticorps Snai1, anticorps sna, anticorps snail, anticorps snai1.S, anticorps LOC410464, anticorps snai1b, anticorps snai1a

Sujet:

Description: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Gene: SNAI1

Poids moléculaire: 29kDa

ID gène: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling