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c-FOS anticorps (pSer362)

c-Fos Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256296
  • Antigène Voir toutes c-FOS (c-Fos) Anticorps
    c-FOS (c-Fos) (c-Fos)
    Épitope
    • 55
    • 26
    • 25
    • 25
    • 19
    • 16
    • 15
    • 15
    • 11
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer362
    Reactivité
    • 248
    • 155
    • 136
    • 13
    • 12
    • 11
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 201
    • 73
    • 8
    • 1
    Lapin
    Clonalité
    • 198
    • 84
    Polyclonal
    Conjugué
    • 113
    • 17
    • 15
    • 15
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    Cet anticorp c-FOS est non-conjugé
    Application
    • 242
    • 80
    • 80
    • 77
    • 64
    • 40
    • 34
    • 26
    • 13
    • 13
    • 12
    • 6
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-c-Fos (Ser362) Antibody detects endogenous levels of c-Fos only when phosphorylated at Serine 362.
    Homologie
    Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human c-Fos around the phosphorylation site of Ser362.
    Isotype
    IgG
    Top Product
    Discover our top product c-Fos Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    c-FOS (c-Fos) (c-Fos)
    Autre désignation
    FOS (c-Fos Produits)
    Synonymes
    anticorps AP-1, anticorps C-FOS, anticorps p55, anticorps c-fos, anticorps D12Rfj1, anticorps cFos, anticorps cFOS, anticorps fos, anticorps Fos proto-oncogene, AP-1 transcription factor subunit, anticorps FBJ osteosarcoma oncogene, anticorps proto-oncogene c-Fos-like, anticorps FOS, anticorps Fos, anticorps LOC101078177
    Sujet

    Description: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

    Gene: FOS

    Poids moléculaire
    40kDa
    ID gène
    2353
    UniProt
    P01100
    Pathways
    S100 Proteins
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