GRLF1 anticorps (pTyr1105)

N° du produit ABIN6256617

Détail du produit anti-GRLF1 anticorps

Antigène: GRLF1 (Glucocorticoid Receptor DNA Binding Factor 1 (GRLF1))

Épitope: pTyr1105

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRLF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Phospho-GRF-1 (Tyr1105) Antibody detects endogenous levels of GRF-1 only when phosphorylated at Tyrosine 1105.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human GRF-1 around the phosphorylation site of Tyr1105.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GRLF1

Antigène: GRLF1 (Glucocorticoid Receptor DNA Binding Factor 1 (GRLF1))

Autre désignation: ARHGAP35 (GRLF1 Produits)

Synonymes: anticorps GRF-1, anticorps GRLF1, anticorps P190-A, anticorps P190A, anticorps p190ARhoGAP, anticorps p190RhoGAP, anticorps 6430596G11Rik, anticorps AI841135, anticorps Arhgap35, anticorps mKIAA1722, anticorps p190A, anticorps Grlf1, anticorps p190-A, anticorps arhgap35, anticorps grf-1, anticorps grlf1, anticorps p190-a, anticorps p190a, anticorps p190arhogap, anticorps p190rhogap, anticorps Rho GTPase activating protein 35, anticorps Rho GTPase activating protein 35 L homeolog, anticorps ARHGAP35, anticorps Arhgap35, anticorps arhgap35.L

Sujet:

Description: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3', this function is however unclear and would need additional experimental evidences (PubMed:1894621).

Gene: ARHGAP35

Poids moléculaire: 155kDa

ID gène: 2909

UniProt: Q9NRY4

Pathways: Tube Formation