NR2F6 anticorps (N-Term)

N° du produit ABIN6257153

Détail du produit anti-NR2F6 anticorps

Antigène: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR2F6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: NR2F6 Antibody detects endogenous levels of total NR2F6.

Homologie: Pig,Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NR2F6, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NR2F6

Antigène: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Autre désignation: NR2F6 (NR2F6 Produits)

Synonymes: anticorps EAR-2, anticorps EAR2, anticorps ERBAL2, anticorps AV090102, anticorps COUP-TF3, anticorps Erbal2, anticorps COUP(II), anticorps NR2F6, anticorps couptf2, anticorps fc94g11, anticorps wu:fc94g11, anticorps zgc:77259, anticorps ear-2, anticorps ear2, anticorps erbal2, anticorps nr2f6l, anticorps wu:fc72d04, anticorps zgc:77260, anticorps nuclear receptor subfamily 2 group F member 6, anticorps nuclear receptor subfamily 2, group F, member 6, anticorps nuclear receptor subfamily 2, group F, member 6a, anticorps nuclear receptor subfamily 2 group F member 6 L homeolog, anticorps nuclear receptor subfamily 2, group F, member 6b, anticorps NR2F6, anticorps Nr2f6, anticorps nr2f6a, anticorps nr2f6.L, anticorps nr2f6, anticorps nr2f6b

Sujet:

Description: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock, is required early in the development of the locus coeruleus (LC).

Gene: NR2F6

Poids moléculaire: 42 kDa

ID gène: 2063

UniProt: P10588

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism