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PKN1 anticorps (Internal Region)

PKN1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257420
  • Antigène Voir toutes PKN1 Anticorps
    PKN1 (Protein Kinase N1 (PKN1))
    Épitope
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 33
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 13
    Lapin
    Clonalité
    • 23
    • 11
    Polyclonal
    Conjugué
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PKN1 est non-conjugé
    Application
    • 19
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    PKN1 Antibody detects endogenous levels of total PKN1.
    Homologie
    Pig,Bovine,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PKN1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PKN1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PKN1 (Protein Kinase N1 (PKN1))
    Autre désignation
    PKN1 (PKN1 Produits)
    Synonymes
    anticorps DBK, anticorps PAK-1, anticorps PAK1, anticorps PKN, anticorps PKN-ALPHA, anticorps PRK1, anticorps PRKCL1, anticorps F730027O18Rik, anticorps Pkn, anticorps Prkcl1, anticorps Stk3, anticorps PKN1, anticorps 3-2, anticorps CG2049, anticorps CG2055, anticorps CT6637, anticorps CT6660, anticorps DPKN, anticorps Dmel\\CG2049, anticorps Dpkn, anticorps PRK2, anticorps Pk45C, anticorps Pk?3, anticorps dPKN, anticorps l(2)06736, anticorps l(2)45Ca, anticorps v(2)rG232, anticorps protein kinase N1, anticorps protein kinase N1b, anticorps Protein kinase N, anticorps PKN1, anticorps Pkn1, anticorps pkn1b, anticorps pkn1, anticorps Pkn
    Sujet

    Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

    Gene: PKN1

    Poids moléculaire
    103 kDa
    ID gène
    5585
    UniProt
    Q16512
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