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Sorting Nexin 3 anticorps (Internal Region)

SNX3 Reactivité: Humain, Souris, Rat ELISA, WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257497
  • Antigène Voir toutes Sorting Nexin 3 (SNX3) Anticorps
    Sorting Nexin 3 (SNX3)
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 36
    • 9
    • 7
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 35
    • 1
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Sorting Nexin 3 est non-conjugé
    Application
    • 24
    • 23
    • 6
    • 5
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    SNX3 Antibody detects endogenous levels of total SNX3.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SNX3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SNX3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Sorting Nexin 3 (SNX3)
    Autre désignation
    SNX3 (SNX3 Produits)
    Synonymes
    anticorps SNX3, anticorps sdp3, anticorps Grd19, anticorps snx3a, anticorps wu:fb53a08, anticorps zgc:123189, anticorps MCOPS8, anticorps SDP3, anticorps sorting nexin 3, anticorps sorting nexin 3 L homeolog, anticorps potential phosphoinositide-binding protein similar to S. cerevisiae GRD19 (YOR357C) late Golgi protein involved in retrieval of proteins from prevacuolar compartment; same as cosmid orf Ca41C10.03, anticorps SNX3, anticorps snx3.L, anticorps snx3, anticorps GRD19, anticorps Snx3
    Sujet

    Description: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes, the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).

    Gene: SNX3

    Poids moléculaire
    18 kDa
    ID gène
    8724
    UniProt
    O60493
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