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RNF138 anticorps (Internal Region)

RNF138 Reactivité: Humain, Souris, Rat WB, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257503
  • Antigène Voir toutes RNF138 Anticorps
    RNF138 (Ring Finger Protein 138 (RNF138))
    Épitope
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 50
    • 26
    • 24
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 48
    • 3
    Lapin
    Clonalité
    • 50
    • 1
    Polyclonal
    Conjugué
    • 22
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RNF138 est non-conjugé
    Application
    • 44
    • 22
    • 13
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    RNF138 Antibody detects endogenous levels of total RNF138.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human RNF138, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RNF138 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RNF138 (Ring Finger Protein 138 (RNF138))
    Autre désignation
    RNF138 (RNF138 Produits)
    Synonymes
    anticorps 2410015A17Rik, anticorps 2810480D20Rik, anticorps STRIN, anticorps Trif, anticorps Trif-d, anticorps HSD-4, anticorps NARF, anticorps hNARF, anticorps Rsd4, anticorps narf, anticorps ring finger protein 138, anticorps ring finger protein 138 S homeolog, anticorps RNF138, anticorps Rnf138, anticorps rnf138.S
    Sujet

    Description: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

    Gene: RNF138

    Poids moléculaire
    28 kDa
    ID gène
    51444
    UniProt
    Q8WVD3
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