TEAD1 anticorps (Internal Region)

N° du produit ABIN6257778

Détail du produit anti-TEAD1 anticorps

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEAD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: TEAD1 Antibody detects endogenous levels of total TEAD1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TEAD1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl,sodium azide and glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TEAD1

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Autre désignation: TEAD1 (TEAD1 Produits)

Synonymes: anticorps tead1, anticorps zgc:63696, anticorps TEAD1, anticorps xtead1, anticorps 2610024B07Rik, anticorps B230114H05Rik, anticorps Gtrgeo5, anticorps TEAD-1, anticorps TEF-1, anticorps Tcf13, anticorps mTEF-1, anticorps AA, anticorps NTEF-1, anticorps REF1, anticorps TCF-13, anticorps TCF13, anticorps XNTEF-1, anticorps xlNTEF-1, anticorps TEA domain family member 1a, anticorps TEA domain transcription factor 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor), anticorps TEA domain family member 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog, anticorps TEA domain family member 1b, anticorps tead1a, anticorps TEAD1, anticorps tead1, anticorps Tead1, anticorps tead1.S, anticorps tead1b

Sujet:

Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene: TEAD1

Poids moléculaire: 48 kDa

ID gène: 7003

UniProt: P28347

Pathways: Regulation of Lipid Metabolism by PPARalpha