PHACTR4 anticorps (Internal Region)
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- Antigène Voir toutes PHACTR4 Anticorps
- PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))
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Épitope
- Internal Region
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PHACTR4 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- PHACTR4 Antibody detects endogenous levels of total PHACTR4.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PHACTR4, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PHACTR4 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))
- Autre désignation
- PHACTR4 (PHACTR4 Produits)
- Synonymes
- anticorps 3110001B12Rik, anticorps AI527228, anticorps AW495572, anticorps C330013F19Rik, anticorps N28169, anticorps mKIAA4120, anticorps phactr4, anticorps zgc:63484, anticorps zgc:123224, anticorps phosphatase and actin regulator 4, anticorps phosphatase and actin regulator 4b, anticorps phosphatase and actin regulator 4 L homeolog, anticorps phosphatase and actin regulator 4 S homeolog, anticorps phosphatase and actin regulator 4a, anticorps Phactr4, anticorps phactr4b, anticorps PHACTR4, anticorps phactr4.L, anticorps phactr4.S, anticorps Tsp_08786, anticorps phactr4, anticorps phactr4a
- Sujet
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Description: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Gene: PHACTR4
- Poids moléculaire
- 80 kDa
- ID gène
- 65979
- UniProt
- Q8IZ21
- Pathways
- Tube Formation
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