RED1 anticorps (Adenosine Deaminase, RNA-Specific, B1)

Details for Product anti-ADARB1 Antibody No. ABIN6257927, Fournisseur: Connectez-vous pour afficher
Antigène
  • ADARB1
  • RED1
  • ADAR2
  • DRABA2
  • DRADA2
  • 1700057H01Rik
  • AW124433
  • AW558573
  • Adar2
  • BB220382
  • D10Bwg0447e
  • Red1
  • adar2
  • adarb1
  • red1
  • adenosine deaminase, RNA specific B1
  • adenosine deaminase, RNA-specific, B1
  • adenosine deaminase, RNA-specific, B1 L homeolog
  • adenosine deaminase, RNA-specific, B1a
  • ADARB1
  • adarb1
  • adarb1.L
  • Adarb1
  • adarb1a
Reactivité
Humain, Souris, Rat (Rattus)
34
25
19
4
3
3
2
2
2
1
1
1
1
Hôte
Lapin
25
9
4
Clonalité
Polyclonal
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
37
12
9
8
3
3
3
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène A synthesized peptide
Isotype IgG
Specificité ADARB1 Antibody detects endogenous levels of total ADARB1
 Réactivité croisée Humain, Souris, Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Plasmids, Primers & others Plasmids, Primers & others RED1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation ADARB1 (ADARB1 Antibody Extrait)
Sujet

Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, pre-mRNA splicing by altering splice site recognition sequences, RNA stability by changing sequences involved in nuclease recognition, genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.

Gene: ADARB1

Poids moléculaire 80 kDa
ID gène 104
UniProt P78563
Indications d'application WB 1:500~1:1000, IF/ICC 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) antibody (ABIN6257927) Western blot analysis of extracts from 293, using ADARB1 Antibody. Lane 1 was treated...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) antibody (ABIN6257927) ABIN6274304 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permea...
Western Blotting (WB) image for anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) antibody (ABIN6257927) Western blot analysis of extracts from HepG2 cells, using ADARB1 antibody.The lane on...
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