Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

RED1 anticorps (Internal Region)

ADARB1 Reactivité: Humain, Rat, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257927
  • Antigène Voir toutes RED1 (ADARB1) Anticorps
    RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))
    Épitope
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 24
    • 19
    • 16
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 20
    • 4
    • 3
    Lapin
    Clonalité
    • 25
    • 2
    Polyclonal
    Conjugué
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RED1 est non-conjugé
    Application
    • 20
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    ADARB1 Antibody detects endogenous levels of total ADARB1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human ADARB1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ADARB1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))
    Autre désignation
    ADARB1 (ADARB1 Produits)
    Synonymes
    anticorps ADARB1, anticorps RED1, anticorps ADAR2, anticorps DRABA2, anticorps DRADA2, anticorps 1700057H01Rik, anticorps AW124433, anticorps AW558573, anticorps Adar2, anticorps BB220382, anticorps D10Bwg0447e, anticorps Red1, anticorps adar2, anticorps adarb1, anticorps red1, anticorps adenosine deaminase, RNA specific B1, anticorps adenosine deaminase, RNA-specific, B1, anticorps adenosine deaminase, RNA-specific, B1 L homeolog, anticorps adenosine deaminase, RNA-specific, B1a, anticorps ADARB1, anticorps adarb1, anticorps adarb1.L, anticorps Adarb1, anticorps adarb1a
    Sujet

    Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, pre-mRNA splicing by altering splice site recognition sequences, RNA stability by changing sequences involved in nuclease recognition, genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.

    Gene: ADARB1

    Poids moléculaire
    80 kDa
    ID gène
    104
    UniProt
    P78563
Vous êtes ici:
Support technique