PRKG2 anticorps (N-Term)

N° du produit ABIN6258017

Détail du produit anti-PRKG2 anticorps

Antigène: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKG2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CGK2 Antibody detects endogenous levels of total CGK2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CGK2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PRKG2

Antigène: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Autre désignation: PRKG2 (PRKG2 Produits)

Synonymes: anticorps MGC82580, anticorps PRKG2, anticorps si:dkey-18e17.2, anticorps PRKGR2, anticorps cGKII, anticorps GDPKII, anticorps AW212535, anticorps CGKII, anticorps Prkgr2, anticorps cGK-II, anticorps protein kinase, cGMP-dependent, type II, anticorps protein kinase, cGMP-dependent, type II L homeolog, anticorps cGMP-dependent protein kinase 2, anticorps PRKG2, anticorps prkg2.L, anticorps prkg2, anticorps LOC100541294, anticorps Prkg2

Sujet:

Description: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).

Gene: PRKG2

Poids moléculaire: 87 kDa

ID gène: 5593

UniProt: Q13237