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CXCR7 anticorps (Internal Region)

CXCR7 Reactivité: Humain, Souris, Rat WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258040
  • Antigène Voir toutes CXCR7 Anticorps
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Épitope
    • 20
    • 14
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 104
    • 46
    • 43
    • 8
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 86
    • 17
    • 1
    Lapin
    Clonalité
    • 76
    • 27
    • 1
    Polyclonal
    Conjugué
    • 42
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CXCR7 est non-conjugé
    Application
    • 74
    • 40
    • 35
    • 19
    • 16
    • 16
    • 13
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    CXCR7 Antibody detects endogenous levels of total CXCR7.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CXCR7, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CXCR7 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Autre désignation
    ACKR3 (CXCR7 Produits)
    Synonymes
    anticorps CMKOR1, anticorps CXC-R7, anticorps CXCR-7, anticorps CXCR7, anticorps GPR159, anticorps RDC-1, anticorps RDC1, anticorps AW541270, anticorps Cmkor1, anticorps Cxcr7, anticorps Rdc1, anticorps ackr3, anticorps cxcr7, anticorps rdc1, anticorps xcxcr7, anticorps atypical chemokine receptor 3, anticorps ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74, anticorps atypical chemokine receptor 3 L homeolog, anticorps ACKR3, anticorps MmrVgp88, anticorps Ackr3, anticorps ackr3.L
    Sujet

    Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

    Gene: ACKR3

    Poids moléculaire
    41 kDa
    ID gène
    57007
    UniProt
    P25106
    Pathways
    Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
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