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S1PR1 anticorps (Internal Region)

S1PR1 Reactivité: Humain, Souris WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258138
  • Antigène Voir toutes S1PR1 Anticorps
    S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
    Épitope
    • 15
    • 11
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 94
    • 59
    • 45
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 92
    • 8
    Lapin
    Clonalité
    • 82
    • 18
    Polyclonal
    Conjugué
    • 53
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp S1PR1 est non-conjugé
    Application
    • 77
    • 43
    • 15
    • 15
    • 14
    • 13
    • 12
    • 8
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    EDG1 Antibody detects endogenous levels of total EDG1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human EDG1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product S1PR1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
    Autre désignation
    S1PR1 (S1PR1 Produits)
    Synonymes
    anticorps CD363, anticorps CHEDG1, anticorps D1S3362, anticorps ECGF1, anticorps EDG-1, anticorps EDG1, anticorps S1P1, anticorps AI849002, anticorps Edg1, anticorps Lpb1, anticorps S1p, anticorps S1p1, anticorps S1P receptor 1, anticorps S1P receptor Edg-1, anticorps edg1, anticorps etID43307.22, anticorps s1p1, anticorps wu:fb98f05, anticorps s1pr1, anticorps xts1p1, anticorps sphingosine-1-phosphate receptor 1, anticorps sphingosine-1-phosphate receptor 1 L homeolog, anticorps S1PR1, anticorps S1pr1, anticorps s1pr1, anticorps s1pr1.L
    Sujet

    Description: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

    Gene: S1PR1

    Poids moléculaire
    43 kDa
    ID gène
    1901
    UniProt
    P21453
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2
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