USP19 anticorps (Internal Region)

N° du produit ABIN6258348

Détail du produit anti-USP19 anticorps

Antigène: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP19 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: USP19 Antibody detects endogenous levels of total USP19.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human USP19, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur USP19

Antigène: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Autre désignation: USP19 (USP19 Produits)

Synonymes: anticorps wu:fc26a05, anticorps si:dkey-32e6.9, anticorps USP19, anticorps MGC145127, anticorps ZMYND9, anticorps 8430421I07Rik, anticorps AI047774, anticorps Zmynd9, anticorps ubiquitin specific peptidase 19, anticorps universal stress protein, anticorps ubiquitin carboxyl-terminal hydrolase 19, anticorps usp19, anticorps USP19, anticorps RR_RS18085, anticorps PTRG_09611, anticorps Usp19

Sujet:

Description: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.

Gene: USP19

Poids moléculaire: 130 kDa

ID gène: 10869

UniProt: O94966