WWTR1 anticorps (Internal Region)

N° du produit ABIN6258356

Détail du produit anti-WWTR1 anticorps

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWTR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: TAZ Antibody detects endogenous levels of total TAZ.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TAZ, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur WWTR1

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Autre désignation: WWTR1 (WWTR1 Produits)

Synonymes: anticorps WWTR1, anticorps TAZ, anticorps 2310058J06Rik, anticorps 2610021I22Rik, anticorps C78399, anticorps Taz, anticorps WW domain containing transcription regulator 1 L homeolog, anticorps WW domain containing transcription regulator 1, anticorps wwtr1.L, anticorps wwtr1, anticorps WWTR1, anticorps Wwtr1

Sujet:

Description: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Gene: WWTR1

Poids moléculaire: 44 kDa

ID gène: 25937

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha