EIF3D anticorps (Internal Region)

N° du produit ABIN6258372

Détail du produit anti-EIF3D anticorps

Antigène: EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: EIF3D Antibody detects endogenous levels of total EIF3D.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EIF3D, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EIF3D

Antigène: EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))

Autre désignation: EIF3D (EIF3D Produits)

Synonymes: anticorps eif3s7, anticorps eIF3d, anticorps DDBDRAFT_0217568, anticorps DDBDRAFT_0219927, anticorps DDB_0217568, anticorps DDB_0219927, anticorps EIF3S7, anticorps An15g03780, anticorps AO090026000811, anticorps eIF3-p66, anticorps eIF3-zeta, anticorps 66/67kDa, anticorps AA407891, anticorps Eif3s7, anticorps eIF3p66, anticorps wu:fb12a03, anticorps zgc:64097, anticorps eukaryotic translation initiation factor 3 subunit D, anticorps eukaryotic translation initiation factor 3 subunit 7, anticorps eukaryotic initiation factor, anticorps eIF-3 zeta, anticorps eukaryotic translation initiation factor 3, subunit D, anticorps translation initiation factor eIF-3 subunit 7, anticorps eukaryotic translation initiation factor 3 subunit D S homeolog, anticorps Eukaryotic translation initiation factor 3 subunit D, anticorps eif3d, anticorps EIF3D, anticorps eIF3-S7, anticorps ANI_1_540134, anticorps AOR_1_1456014, anticorps PTRG_07832, anticorps VDBG_06053, anticorps PGTG_10613, anticorps Tsp_00484, anticorps Eif3d, anticorps eif3d.S, anticorps eif-3.D

Sujet:

Description: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).

Gene: EIF3D

Poids moléculaire: 64 kDa

ID gène: 8664

UniProt: O15371

Pathways: Ribonucleoprotein Complex Subunit Organization