UBE2D3 anticorps

N° du produit ABIN6258377

Détail du produit anti-UBE2D3 anticorps

Antigène: UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2D3 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: UBE2D3 antibody detects endogenous levels of total UBE2D3

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur UBE2D3

Antigène: UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))

Autre désignation: UBE2D3 (UBE2D3 Produits)

Synonymes: anticorps E2(17)KB3, anticorps UBC4/5, anticorps UBCH5C, anticorps eff, anticorps fb36f02, anticorps wu:fb36f02, anticorps zgc:56340, anticorps 1100001F19Rik, anticorps 9430029A22Rik, anticorps AA414951, anticorps UBE2D3P, anticorps Xubc4, anticorps e2(17)kb3, anticorps ubc4/5, anticorps ubch5c, anticorps ube2d3.1, anticorps ube2d2, anticorps xubc4, anticorps wu:fj13d01, anticorps zgc:73200, anticorps ubiquitin conjugating enzyme E2 D3, anticorps ubiquitin-conjugating enzyme E2D 3, anticorps ubiquitin conjugating enzyme E2 D3 L homeolog, anticorps ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like, anticorps UBE2D3, anticorps ube2d3, anticorps Ube2d3, anticorps LOC100223566, anticorps ube2d3.L, anticorps ube2d2l

Sujet:

Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.

Gene: UBE2D3

Poids moléculaire: 17 kDa

ID gène: 7323

UniProt: P61077

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades