POU4F1 anticorps (Internal Region)

N° du produit ABIN6258459

Détail du produit anti-POU4F1 anticorps

Antigène: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POU4F1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: POU4F1 Antibody detects endogenous levels of total POU4F1.

Homologie: Pig,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human POU4F1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur POU4F1

Antigène: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Autre désignation: POU4F1 (POU4F1 Produits)

Synonymes: anticorps BRN3A, anticorps Oct-T1, anticorps RDC-1, anticorps brn-3A, anticorps POU4F1, anticorps Brn-3a, anticorps Brn-3, anticorps Brn-3.0, anticorps Brn3, anticorps Brn3.0, anticorps Brn3a, anticorps E130119J07Rik, anticorps brn3.0, anticorps brn3a, anticorps brn3a-A, anticorps oct-t1, anticorps rdc-1, anticorps POU class 4 homeobox 1, anticorps POU domain, class 4, transcription factor 1, anticorps POU class 4 homeobox 1 L homeolog, anticorps POU4F1, anticorps Pou4f1, anticorps pou4f1, anticorps Tsp_01181, anticorps pou4f1.L

Sujet:

Description: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.

Gene: POU4F1

Poids moléculaire: 42 kDa

ID gène: 5457

UniProt: Q01851

Pathways: Feeding Behaviour