USP44 anticorps (Internal Region)

N° du produit ABIN6258564

Détail du produit anti-USP44 anticorps

Antigène: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP44 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: USP44 Antibody detects endogenous levels of total USP44.

Homologie: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human USP44, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur USP44

Antigène: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Autre désignation: USP44 (USP44 Produits)

Synonymes: anticorps usp44, anticorps USP49, anticorps E430004F17Rik, anticorps zgc:55661, anticorps ubiquitin specific peptidase 44, anticorps ubiquitin specific peptidase 44 L homeolog, anticorps ubiquitin specific peptidase 44 S homeolog, anticorps USP44, anticorps usp44.L, anticorps usp44.S, anticorps usp44, anticorps Usp44

Sujet:

Description: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

Gene: USP44

Poids moléculaire: 81 kDa

ID gène: 84101

UniProt: Q9H0E7

Pathways: M Phase