Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

MAP4K2 anticorps (Internal Region)

MAP4K2 Reactivité: Humain WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258837
  • Antigène Voir toutes MAP4K2 Anticorps
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Épitope
    • 12
    • 12
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 43
    • 28
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 55
    • 1
    Lapin
    Clonalité
    • 56
    Polyclonal
    Conjugué
    • 22
    • 6
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAP4K2 est non-conjugé
    Application
    • 46
    • 37
    • 13
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    MAP4K2 Antibody detects endogenous levels of total MAP4K2.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human MAP4K2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MAP4K2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Autre désignation
    MAP4K2 (MAP4K2 Produits)
    Synonymes
    anticorps BL44, anticorps GCK, anticorps RAB8IP, anticorps AI385662, anticorps Rab8ip, anticorps MAP4K2, anticorps dZ150L22.2, anticorps map4k2l, anticorps map4k2l-2, anticorps map4k3l, anticorps si:dz150l22.2, anticorps si:dz263j20.1, anticorps zgc:136670, anticorps mitogen-activated protein kinase kinase kinase kinase 2, anticorps mitogen activated protein kinase kinase kinase kinase 2, anticorps MAP4K2, anticorps Map4k2, anticorps LOC103346779, anticorps map4k2
    Sujet

    Description: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

    Gene: MAP4K2

    Poids moléculaire
    91 kDa
    ID gène
    5871
    UniProt
    Q12851
Vous êtes ici:
Support technique