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HMGB2 anticorps (Internal Region)

HMGB2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258843
  • Antigène Voir toutes HMGB2 Anticorps
    HMGB2 (High Mobility Group Box 2 (HMGB2))
    Épitope
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 57
    • 29
    • 21
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 45
    • 12
    Lapin
    Clonalité
    • 43
    • 14
    Polyclonal
    Conjugué
    • 39
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp HMGB2 est non-conjugé
    Application
    • 38
    • 20
    • 15
    • 14
    • 11
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    HMGB2 Antibody detects endogenous levels of total HMGB2.
    Homologie
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human HMGB2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product HMGB2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    HMGB2 (High Mobility Group Box 2 (HMGB2))
    Autre désignation
    HMGB2 (HMGB2 Produits)
    Synonymes
    anticorps HMG2, anticorps C80539, anticorps HMG-2, anticorps Hmg2, anticorps HIGH MOBILITY GROUP BETA 1, anticorps HMG BETA 1, anticorps NFD02, anticorps NFD2, anticorps NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 02, anticorps NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 2, anticorps high mobility group B2, anticorps hmgb2, anticorps hmgb2l, anticorps im:6909096, anticorps wu:fa20b02, anticorps zgc:101854, anticorps wu:fb22b10, anticorps wu:fc95d12, anticorps zgc:123215, anticorps high mobility group box 2, anticorps high mobility group box 2 S homeolog, anticorps high mobility group B2, anticorps high mobility group box 2b, anticorps high mobility group box 2a, anticorps HMGB2, anticorps Hmgb2, anticorps hmgb2.S, anticorps hmgb2b, anticorps hmgb2a
    Sujet

    Description: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

    Gene: HMGB2

    Poids moléculaire
    27 kDa
    ID gène
    3148
    UniProt
    P26583
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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