MUL1 anticorps (Internal Region)
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- Antigène Voir toutes MUL1 Anticorps
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MUL1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- MUL1 Antibody detects endogenous levels of total MUL1.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human MUL1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product MUL1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
- Autre désignation
- MUL1 (MUL1 Produits)
- Synonymes
- anticorps C1orf166, anticorps GIDE, anticorps MAPL, anticorps MULAN, anticorps RNF218, anticorps RP11-401M16.2, anticorps mul1, anticorps zgc:92166, anticorps 0610009K11Rik, anticorps AV000801, anticorps Gide, anticorps RGD1309944, anticorps im:7146383, anticorps zgc:165594, anticorps mitochondrial E3 ubiquitin protein ligase 1, anticorps mitochondrial E3 ubiquitin protein ligase 1 L homeolog, anticorps mitochondrial E3 ubiquitin protein ligase 1a, anticorps mitochondrial ubiquitin ligase activator of NFKB 1, anticorps mitochondrial E3 ubiquitin protein ligase 1b, anticorps MUL1, anticorps mul1.L, anticorps mul1a, anticorps Mul1, anticorps mul1b
- Sujet
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Description: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).
Gene: MUL1
- Poids moléculaire
- 38 kDa
- ID gène
- 79594
- UniProt
- Q969V5
- Pathways
- Positive Regulation of Endopeptidase Activity
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