ACVR2B anticorps (Internal Region)

N° du produit ABIN6259761

Détail du produit anti-ACVR2B anticorps

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACVR2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: ACVR2B Antibody detects endogenous levels of total ACVR2B.

Homologie: Pig,Bovine,Horse,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ACVR2B, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ACVR2B

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Autre désignation: ACVR2B (ACVR2B Produits)

Synonymes: anticorps ACVR2B, anticorps XAR1, anticorps actr-iib, anticorps actriib, anticorps ACTRIIB, anticorps ActR-IIB, anticorps HTX4, anticorps ActRIIB, anticorps actr2b, anticorps actrIIb, anticorps wu:fj97d11, anticorps activin A receptor type 2B, anticorps activin A receptor type 2B L homeolog, anticorps activin A receptor type 2Ba, anticorps activin receptor IIB, anticorps ACVR2B, anticorps acvr2b, anticorps acvr2b.L, anticorps Acvr2b, anticorps acvr2ba

Sujet:

Description: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Gene: ACVR2B

Poids moléculaire: 58 kDa

ID gène: 93

UniProt: Q13705

Pathways: Hormone Transport, Cancer Immune Checkpoints