ADAM10 anticorps (Internal Region)
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- Antigène Voir toutes ADAM10 Anticorps
- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ADAM10 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificité
- ADAM10 Antibody detects endogenous levels of total ADAM10.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ADAM10, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ADAM10 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
- Autre désignation
- ADAM10 (ADAM10 Produits)
- Synonymes
- anticorps ADAM10, anticorps Adam10, anticorps adam10, anticorps wu:fc03d12, anticorps ad10, anticorps cd156c, anticorps kuz, anticorps kuzbanian, anticorps madm, anticorps xadam10, anticorps ADAM-10, anticorps ADAM 10, anticorps AD10, anticorps CD156c, anticorps HsT18717, anticorps MADM, anticorps 1700031C13Rik, anticorps LOC100219653, anticorps zgc:64203, anticorps ADAM metallopeptidase domain 10, anticorps ADAM metallopeptidase domain 10a, anticorps ADAM metallopeptidase domain 10 S homeolog, anticorps a disintegrin and metallopeptidase domain 10, anticorps ADAM metallopeptidase domain 10b, anticorps ADAM10, anticorps Adam10, anticorps adam10a, anticorps adam10.S, anticorps adam10b
- Sujet
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Description: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).
Gene: ADAM10
- Poids moléculaire
- 84 kDa
- ID gène
- 102
- UniProt
- O14672
- Pathways
- Signalisation Notch, EGFR Signaling Pathway
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