ALKBH7 anticorps
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- Antigène Voir toutes ALKBH7 Anticorps
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ALKBH7 est non-conjugé
- Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- ALKBH7 Antibody detects endogenous levels of total ALKBH7
- Réactivité croisée
- Humain, Souris
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ALKBH7
- Isotype
- IgG
- Top Product
- Discover our top product ALKBH7 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000 IHC 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
- Autre désignation
- ALKBH7 (ALKBH7 Produits)
- Synonymes
- anticorps ABH7, anticorps SPATA11, anticorps UNQ6002, anticorps 2310045B01Rik, anticorps 2510008E23Rik, anticorps Abh7, anticorps Spata11, anticorps alkB homolog 7, anticorps Alkbh7, anticorps ALKBH7
- Sujet
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Description: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Gene: ALKBH7
- Poids moléculaire
- 24 kDa
- ID gène
- 84266
- UniProt
- Q9BT30
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