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AP2A2 anticorps (Internal Region)

AP2A2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259963
  • Antigène Voir toutes AP2A2 Anticorps
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Épitope
    • 15
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 41
    • 28
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 40
    • 1
    Lapin
    Clonalité
    • 41
    Polyclonal
    Conjugué
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AP2A2 est non-conjugé
    Application
    • 33
    • 13
    • 13
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    AP2A2 Antibody detects endogenous levels of total AP2A2.
    Homologie
    Bovine,Horse,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human AP2A2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product AP2A2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Autre désignation
    AP2A2 (AP2A2 Produits)
    Synonymes
    anticorps MGC99219, anticorps ADTAB, anticorps CLAPA2, anticorps HIP-9, anticorps HIP9, anticorps HYPJ, anticorps 2410074K14Rik, anticorps AF006990, anticorps AW146353, anticorps Adtab, anticorps C78001, anticorps L25, anticorps adaptor related protein complex 2 alpha 2 subunit, anticorps adaptor related protein complex 2 alpha 2 subunit L homeolog, anticorps adaptor-related protein complex 2, alpha 2 subunit, anticorps AP2A2, anticorps ap2a2.L, anticorps Ap2a2
    Sujet

    Description: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).

    Gene: AP2A2

    Poids moléculaire
    104kDa
    ID gène
    161
    UniProt
    O94973
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
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