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APC anticorps (Internal Region)

APC Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259974
  • Antigène Voir toutes APC Anticorps
    APC (Adenomatous Polyposis Coli (APC))
    Épitope
    • 20
    • 15
    • 11
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 66
    • 42
    • 33
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 97
    • 7
    • 4
    • 2
    • 1
    Lapin
    Clonalité
    • 88
    • 23
    Polyclonal
    Conjugué
    • 60
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp APC est non-conjugé
    Application
    • 52
    • 31
    • 29
    • 27
    • 26
    • 19
    • 18
    • 12
    • 9
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    APC Antibody detects endogenous levels of total APC .
    Homologie
    Pig,Bovine,Horse
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human APC , corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product APC Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    APC (Adenomatous Polyposis Coli (APC))
    Autre désignation
    APC (APC Produits)
    Synonymes
    anticorps dp2, anticorps dp3, anticorps fap, anticorps fpc, anticorps xapc, anticorps dp2.5, anticorps AI047805, anticorps AU020952, anticorps AW124434, anticorps CC1, anticorps Min, anticorps mAPC, anticorps BTPS2, anticorps DP2, anticorps DP2.5, anticorps DP3, anticorps GS, anticorps PPP1R46, anticorps RATAPC, anticorps APC1, anticorps APC, WNT signaling pathway regulator, anticorps adenomatous polyposis coli, anticorps adenomatous polyposis coli protein, putative, anticorps adenomatosis polyposis coli, anticorps adenomatous polyposis coli L homeolog, anticorps APC, anticorps apc, anticorps Smp_139190, anticorps Apc, anticorps apc.L
    Sujet

    Description: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

    Gene: APC

    Poids moléculaire
    310kDa
    ID gène
    324
    UniProt
    P25054
    Pathways
    Signalisation WNT, Stem Cell Maintenance, Cell-Cell Junction Organization
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