ASPM anticorps (Internal Region)

N° du produit ABIN6260082

Détail du produit anti-ASPM anticorps

Antigène: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Épitope: Internal Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASPM est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting (WB)

Specificité: ASPM Antibody detects endogenous levels of total ASPM.

Homologie: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ASPM, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ASPM

Antigène: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Autre désignation: ASPM (ASPM Produits)

Synonymes: anticorps Calmbp1, anticorps ASPM, anticorps ASP, anticorps MCPH5, anticorps D330028K02Rik, anticorps Sha1, anticorps abnormal spindle microtubule assembly, anticorps asp (abnormal spindle)-like, microcephaly associated (Drosophila), anticorps Aspm, anticorps ASPM, anticorps aspm

Sujet:

Description: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

Gene: ASPM

Poids moléculaire: 410 kDa

ID gène: 259266

UniProt: Q8IZT6