BAZ1B anticorps (Internal Region)

N° du produit ABIN6260206

Détail du produit anti-BAZ1B anticorps

Antigène: BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAZ1B est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: BAZ1B Antibody detects endogenous levels of total BAZ1B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BAZ1B, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BAZ1B

Antigène: BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

Autre désignation: BAZ1B (BAZ1B Produits)

Synonymes: anticorps BAZ1B, anticorps wstf, anticorps wbscr9, anticorps wbscr10, anticorps LOC100220420, anticorps WBSCR10, anticorps WBSCR9, anticorps WSTF, anticorps C87820, anticorps Wbscr9, anticorps fi60d02, anticorps im:7137554, anticorps wu:fi60d02, anticorps bromodomain adjacent to zinc finger domain 1B, anticorps bromodomain adjacent to zinc finger domain, 1B, anticorps bromodomain adjacent to zinc finger domain 1B S homeolog, anticorps BAZ1B, anticorps baz1b, anticorps Baz1b, anticorps baz1b.S

Sujet:

Description: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

Gene: BAZ1B

Poids moléculaire: 185 kDa

ID gène: 9031

UniProt: Q9UIG0

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding