Bcl-2 anticorps

N° du produit ABIN6260222

Détail du produit anti-Bcl-2 anticorps

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Bcl-2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: BCL-2 Antibody detects endogenous levels of total BCL-2

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BCL-2

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Références pour anticorps anti-Bcl-2 (ABIN6260222)

Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: "Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase." dans: Oncotarget, Vol. 7, Issue 26, pp. 39302-39315, (2018) (PubMed).

Li, Cui, Wang, Wang, Li, Qiu, Yu, Liu, Wen, Rao: "Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis." dans: Andrologia, Vol. 49, Issue 7, (2018) (PubMed).

Wang, Li, Li, Pan, Bai, Huang: "Angelicin inhibits liver cancer growth in vitro and in vivo." dans: Molecular medicine reports, Vol. 16, Issue 4, pp. 5441-5449, (2018) (PubMed).

Gao, Ma, Ma, Ding, Xu, Wei, Wei, Zhang: "Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells." dans: Ultrastructural pathology, Vol. 42, Issue 1, pp. 49-54, (2018) (PubMed).

Yin, Meng, Zhang, Hu, Chen, Han, Wu, You, Li, Jin, Guan: "Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer." dans: Journal of controlled release : official journal of the Controlled Release Society, Vol. 271, pp. 31-44, (2018) (PubMed).

Lu, Zhou, Hao, Li, Wang, Shu, Du, Zhu, Zhang, Yin: "The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy." dans: Molecular and cellular endocrinology, Vol. 473, pp. 31-43, (2018) (PubMed).

Shao, Zhang, Ma, Lu, Meng, Li, Wang, Chen, Zhang, Han, Liu, Ma: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." dans: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).

Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." dans: Marine drugs, Vol. 16, Issue 3, (2018) (PubMed).

Wang, Liu, Guo, Quan: "Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 1, pp. 69-81, (2018) (PubMed).

Zhou, Zhang, Liu, Lei, Liu, Jiao, Dang: "Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice." dans: Frontiers in behavioral neuroscience, Vol. 12, pp. 110, (2018) (PubMed).

Wang, Li, Chen, Luo, Gu, Wang, Wu, Xu et al.: "Baicalin extracted from Huangqin (Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 ..." dans: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, Vol. 37, Issue 2, pp. 229-5, (2018) (PubMed).

Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." dans: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).

Zhao, Deng, Xu, Zhang, Mi, Meng, Gou, Xu: "PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury." dans: Cellular and molecular neurobiology, Vol. 37, Issue 4, pp. 707-715, (2017) (PubMed).

Chen, Wu, Gan, Liu, Lv, Shen, Dai, Xu: "Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway." dans: Journal of ethnopharmacology, Vol. 194, pp. 850-860, (2017) (PubMed).

Pan, Zhang, Zhao, Zhou, Wang, Deng: "The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway." dans: Cancer chemotherapy and pharmacology, Vol. 80, Issue 1, pp. 91-100, (2017) (PubMed).

Liu, Liu, He, Zhang, Liu, Wang, Qiu, Xu, Xiang, Lv: "Differential gene and lncRNA expression in the lower thoracic spinal cord following ischemia/reperfusion-induced acute kidney injury in rats." dans: Oncotarget, Vol. 8, Issue 32, pp. 53465-53481, (2017) (PubMed).

Li, Chen, Wang, Wang, Liu: "The effect of cavernous nerve traction on erectile function in rats." dans: PLoS ONE, Vol. 12, Issue 10, pp. e0186077, (2017) (PubMed).

Détails sur Bcl-2

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: BCL-2 (BCL2 Produits)

Synonymes: anticorps Bcl-2, anticorps PPP1R50, anticorps bcl-2, anticorps AW986256, anticorps C430015F12Rik, anticorps D630044D05Rik, anticorps D830018M01Rik, anticorps BCL-2, anticorps Bcl2, anticorps BCL2, apoptosis regulator, anticorps B cell leukemia/lymphoma 2, anticorps B-cell CLL/lymphoma 2a, anticorps B-cell CLL/lymphoma 2 protein, anticorps BCL2, anticorps Bcl2, anticorps bcl2a, anticorps BCL-2

Sujet:

Description: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Gene: BCL2

Poids moléculaire: 26kDa

ID gène: 596

UniProt: P10415

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling