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BHLHE41 anticorps (N-Term)

BHLHE41 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6260257
  • Antigène Voir toutes BHLHE41 Anticorps
    BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))
    Épitope
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 40
    • 21
    • 14
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 31
    • 8
    • 1
    Lapin
    Clonalité
    • 33
    • 7
    Polyclonal
    Conjugué
    • 24
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BHLHE41 est non-conjugé
    Application
    • 29
    • 19
    • 7
    • 4
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    BHLHB3 Antibody detects endogenous levels of total BHLHB3.
    Homologie
    Pig,Bovine,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human BHLHB3, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product BHLHE41 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))
    Autre désignation
    BHLHE41 (BHLHE41 Produits)
    Synonymes
    anticorps BHLHB3, anticorps dec2, anticorps bhlhb3, anticorps sharp1, anticorps sharp-1, anticorps MGC108143, anticorps DEC2, anticorps SHARP1, anticorps hDEC2, anticorps 6430520M22Rik, anticorps Bhlhb2l, anticorps Bhlhb3, anticorps Sharp1, anticorps Dec2, anticorps SHARP-1, anticorps basic helix-loop-helix family member e41, anticorps basic helix-loop-helix family, member e41, anticorps BHLHE41, anticorps bhlhe41, anticorps Bhlhe41
    Sujet

    Description: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

    Gene: BHLHE41

    Poids moléculaire
    50kDa
    ID gène
    79365
    UniProt
    Q9C0J9
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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