CLP1 anticorps

N° du produit ABIN6260896

Détail du produit anti-CLP1 anticorps

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CLP1 Antibody detects endogenous levels of total CLP1

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CLP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur CLP1

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Autre désignation: CLP1 (CLP1 Produits)

Synonymes: anticorps Heab, anticorps RGD1307679, anticorps AI462438, anticorps ACDP1, anticorps CLP-1, anticorps CGP-39, anticorps GP-39, anticorps SPC-40, anticorps SPS-40, anticorps YKL-40, anticorps HEAB, anticorps hClp1, anticorps fa28a12, anticorps wu:fa28a12, anticorps clp1, anticorps cleavage and polyadenylation factor I subunit 1, anticorps CLP1, cleavage and polyadenylation factor I subunit, anticorps cyclin and CBS domain divalent metal cation transport mediator 1, anticorps chitinase 3-like 1 (cartilage glycoprotein-39), anticorps cleavage and polyadenylation factor I subunit 1 L homeolog, anticorps Clp1, anticorps CNNM1, anticorps CHI3L1, anticorps CLP1, anticorps clp1, anticorps clp1.L

Sujet:

Description: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Gene: CLP1

Poids moléculaire: 48 kDa

ID gène: 10978

UniProt: Q92989

Pathways: Ribonucleoprotein Complex Subunit Organization