COPS3 anticorps (C-Term)

N° du produit ABIN6260969

Détail du produit anti-COPS3 anticorps

Antigène: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: COPS3 Antibody detects endogenous levels of total COPS3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human COPS3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IF/ICC: 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur COPS3

Antigène: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Autre désignation: COPS3 (COPS3 Produits)

Synonymes: anticorps CG18332, anticorps CH3, anticorps Csn3, anticorps DCH3, anticorps Dch3, anticorps Dmel\\CG18332, anticorps FBgn0027055, anticorps dCSN3, anticorps COPS3, anticorps CSN3, anticorps DKFZp468P1922, anticorps Sgn3, anticorps wu:fc32a02, anticorps wu:fk59f01, anticorps zgc:111903, anticorps zgc:55643, anticorps zgc:77615, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 13, anticorps COP9 SIGNALOSOME SUBUNIT 3, anticorps F18O22.40, anticorps F18O22_40, anticorps FUS11, anticorps FUSCA 11, anticorps SGN3, anticorps csn3, anticorps COP9 signalosome subunit 3, anticorps Proteasome component (PCI) domain protein, anticorps COP9 signalosome subunit 3 L homeolog, anticorps COP9 signalosome complex subunit 3, anticorps CSN3, anticorps cops3, anticorps COPS3, anticorps Cops3, anticorps COP13, anticorps cops3.L, anticorps csn-3

Sujet:

Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene: COPS3

Poids moléculaire: 47kDa

ID gène: 8533

UniProt: Q9UNS2

Pathways: Cycle Cellulaire