CPSF6 anticorps (Internal Region)

N° du produit ABIN6261008

Détail du produit anti-CPSF6 anticorps

Antigène: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPSF6 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CPSF6 Antibody detects endogenous levels of total CPSF6.

Homologie: Bovine,Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CPSF6

Antigène: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Autre désignation: CPSF6 (CPSF6 Produits)

Synonymes: anticorps CPSF6, anticorps wu:fa22f12, anticorps zgc:85819, anticorps 4733401N12Rik, anticorps AI256641, anticorps CFIM, anticorps CFIM68, anticorps HPBRII-4, anticorps HPBRII-7, anticorps cleavage and polyadenylation specific factor 6, anticorps cleavage and polyadenylation specific factor 6 S homeolog, anticorps CPSF6, anticorps cpsf6.S, anticorps cpsf6, anticorps Cpsf6

Sujet:

Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).

Gene: CPSF6

Poids moléculaire: 59 kDa

ID gène: 11052

UniProt: Q16630