CYP26B1 anticorps (Internal Region)

N° du produit ABIN6261169

Détail du produit anti-CYP26B1 anticorps

Antigène: CYP26B1 (Cytochrome P450, Family 26, Subfamily B, Polypeptide 1 (CYP26B1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP26B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CYP26B1 Antibody detects endogenous levels of total CYP26B1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CYP26B1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CYP26B1

Antigène: CYP26B1 (Cytochrome P450, Family 26, Subfamily B, Polypeptide 1 (CYP26B1))

Autre désignation: CYP26B1 (CYP26B1 Produits)

Synonymes: anticorps cyp26b1, anticorps cyp26a2, anticorps p450rai-2, anticorps CYP26A2, anticorps P450RAI-2, anticorps P450RAI2, anticorps RHFCA, anticorps CP26, anticorps fc21d03, anticorps wu:fc21d03, anticorps wu:fc26h10, anticorps zgc:76999, anticorps cytochrome P450 26B1, anticorps cytochrome P450 family 26 subfamily B member 1 L homeolog, anticorps cytochrome P450 family 26 subfamily B member 1, anticorps cytochrome P450, family 26, subfamily B, polypeptide 1, anticorps cytochrome P450, family 26, subfamily b, polypeptide 1, anticorps CpipJ_CPIJ002537, anticorps cyp26b1.L, anticorps CYP26B1, anticorps cyp26b1, anticorps Cyp26b1

Sujet:

Description: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

Gene: CYP26B1

Poids moléculaire: 58-60 kDa

ID gène: 56603

UniProt: Q9NR63

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Monocarboxylic Acid Catabolic Process