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DDIT4 anticorps (Internal Region)

DDIT4 Reactivité: Humain, Rat, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261248
  • Antigène Voir toutes DDIT4 Anticorps
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Épitope
    • 15
    • 14
    • 13
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 54
    • 23
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Rat, Souris
    Hôte
    • 65
    • 4
    Lapin
    Clonalité
    • 67
    • 2
    Polyclonal
    Conjugué
    • 28
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DDIT4 est non-conjugé
    Application
    • 46
    • 33
    • 26
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA
    Specificité
    DDIT4 Antibody detects endogenous levels of total DDIT4.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human DDIT4, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product DDIT4 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Autre désignation
    DDIT4 (DDIT4 Produits)
    Synonymes
    anticorps redd1, anticorps Dig2, anticorps REDD-1, anticorps REDD1, anticorps 5830413E08Rik, anticorps AA415483, anticorps Rtp801, anticorps dig2, anticorps rtp801, anticorps sb:cb821, anticorps zgc:64114, anticorps DNA damage inducible transcript 4, anticorps DNA-damage-inducible transcript 4, anticorps DNA damage inducible transcript 4 S homeolog, anticorps ddit4, anticorps DDIT4, anticorps Ddit4, anticorps ddit4.S
    Sujet

    Description: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

    Gene: DDIT4

    Poids moléculaire
    25 kDa
    ID gène
    54541
    UniProt
    Q9NX09
    Pathways
    Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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