EIF3I anticorps (C-Term)

N° du produit ABIN6261483

Détail du produit anti-EIF3I anticorps

Antigène: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3I est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: EIF3I Antibody detects endogenous levels of total EIF3I.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EIF3I, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EIF3I

Antigène: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Autre désignation: EIF3I (EIF3I Produits)

Synonymes: anticorps EIF3S2, anticorps PRO2242, anticorps TRIP-1, anticorps TRIP1, anticorps eIF3-beta, anticorps eIF3-p36, anticorps 36kDa, anticorps D4Ertd632e, anticorps Eif3s2, anticorps Trip1, anticorps eIF-3-beta, anticorps eIF3 p36, anticorps eif3s2, anticorps hm:zehn0464, anticorps wu:fb62b08, anticorps zgc:56211, anticorps zgc:77823, anticorps CaO19.2967, anticorps eIF-3 39 kDa subunit homolog, anticorps eIF3i, anticorps eif3-beta, anticorps eif3-p36, anticorps eif3i, anticorps pro2242, anticorps trip-1, anticorps trip1, anticorps eukaryotic translation initiation factor 3 subunit I, anticorps eukaryotic translation initiation factor 3, subunit I, anticorps Eukaryotic Initiation Factor, anticorps Eukaryotic translation initiation factor 3 subunit I, anticorps translation initiation factor eIF3 subunit i, anticorps eukaryotic translation initiation factor 3 subunit I L homeolog, anticorps EIF3I, anticorps Eif3i, anticorps eif-3.I, anticorps eIF3i, anticorps eif3i, anticorps TIF34, anticorps eif3i.L

Sujet:

Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3I

Poids moléculaire: 36 kDa

ID gène: 8668

UniProt: Q13347

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Ribonucleoprotein Complex Subunit Organization, Synthesis of DNA