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ERAP1 anticorps (Internal Region)

ERAP1 Reactivité: Humain WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261584
  • Antigène Voir toutes ERAP1 Anticorps
    ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
    Épitope
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 32
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 30
    • 2
    Lapin
    Clonalité
    • 29
    • 3
    Polyclonal
    Conjugué
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ERAP1 est non-conjugé
    Application
    • 16
    • 14
    • 10
    • 8
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    ERAP1 Antibody detects endogenous levels of total ERAP1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human ERAP1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ERAP1 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
    Autre désignation
    ERAP1 (ERAP1 Produits)
    Synonymes
    anticorps MGC166160, anticorps DKFZp469C044, anticorps ARTS-1, anticorps A-LAP, anticorps ALAP, anticorps APPILS, anticorps ARTS1, anticorps ERAAP, anticorps ERAAP1, anticorps PILS-AP, anticorps PILSAP, anticorps Arts1, anticorps PILSA, anticorps Appils, anticorps endoplasmic reticulum aminopeptidase 1, anticorps endoplasmic reticulum aminopeptidase 1b, anticorps ERAP1, anticorps erap1, anticorps erap1b, anticorps Erap1
    Sujet

    Description: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

    Gene: ERAP1

    Poids moléculaire
    107 kDa
    ID gène
    51752
    UniProt
    Q9NZ08
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