FANCL anticorps (Internal Region)

N° du produit ABIN6261676

Détail du produit anti-FANCL anticorps

Antigène: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCL est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: FANCL Antibody detects endogenous levels of total FANCL.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human FANCL, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur FANCL

Antigène: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Autre désignation: FANCL (FANCL Produits)

Synonymes: anticorps FAAP43, anticorps PHF9, anticorps POG, anticorps 2010322C19Rik, anticorps AW554273, anticorps B230118H11Rik, anticorps Phf9, anticorps Pog, anticorps gcd, anticorps Fanconi anemia complementation group L, anticorps Fanconi anemia, complementation group L, anticorps FANCL, anticorps Fancl

Sujet:

Description: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.

Gene: FANCL

Poids moléculaire: 43 kDa

ID gène: 55120

UniProt: Q9NW38

Pathways: Réparation de l'ADN