HECW1 anticorps (Internal Region)
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- Antigène Voir toutes HECW1 Anticorps
- HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))
- Épitope
- Internal Region
- Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HECW1 est non-conjugé
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- HECW1 Antibody detects endogenous levels of total HECW1.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human HECW1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product HECW1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))
- Autre désignation
- HECW1 (HECW1 Produits)
- Synonymes
- anticorps NEDL1, anticorps 9330116H24Rik, anticorps AV273951, anticorps E130207I19Rik, anticorps Nedl1, anticorps HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1, anticorps HECW1, anticorps Hecw1
- Sujet
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Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Gene: HECW1
- Poids moléculaire
- 180kDa
- ID gène
- 23072
- UniProt
- Q76N89
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