HSPA1L anticorps (Internal Region)

N° du produit ABIN6262409

Détail du produit anti-HSPA1L anticorps

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPA1L est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: HSPA1L Antibody detects endogenous levels of total HSPA1L.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HSPA1L, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HSPA1L

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Autre désignation: HSPA1L (HSPA1L Produits)

Synonymes: anticorps Hsc70t, anticorps Msh5, anticorps HSPA1L, anticorps hspa1l, anticorps MGC147483, anticorps Hsp70-3, anticorps HSP70-1L, anticorps HSP70-HOM, anticorps HSP70T, anticorps hum70t, anticorps heat shock 70kDa protein 1-like, anticorps heat shock protein 1-like, anticorps heat shock 70 kDa protein 1-like, anticorps heat shock protein family A (Hsp70) member 1 like, anticorps HSPA1L, anticorps Hspa1l, anticorps LOC471967, anticorps hspa1l, anticorps LOC474850, anticorps LOC102177850, anticorps LOC100050904

Sujet:

Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Gene: HSPA1L

Poids moléculaire: 70kDa

ID gène: 3305

UniProt: P34931