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IFITM3 anticorps (N-Term)

IFITM3 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6262457
  • Antigène Voir toutes IFITM3 Anticorps
    IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
    Épitope
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 38
    • 5
    • 4
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 29
    • 6
    • 3
    Lapin
    Clonalité
    • 32
    • 6
    Polyclonal
    Conjugué
    • 26
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IFITM3 est non-conjugé
    Application
    • 28
    • 18
    • 10
    • 10
    • 7
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    IFITM3 Antibody detects endogenous levels of total IFITM3.
    Homologie
    Pig,Sheep
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human IFITM3, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product IFITM3 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
    Autre désignation
    IFITM3 (IFITM3 Produits)
    Synonymes
    anticorps 1110004C05Rik, anticorps Cd225, anticorps Cdw217, anticorps DSPA2b, anticorps Fgls, anticorps IP15, anticorps mil-1, anticorps 1-8U, anticorps rat8, anticorps Interferon-induced transmembrane protein 3, anticorps interferon induced transmembrane protein 3, anticorps ifm3, anticorps Ifitm3, anticorps IFITM3
    Sujet

    Description: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the  pH in phagocytic endosomes thus establishing an antiviral state.

    Gene: IFITM3

    Poids moléculaire
    15 kDa
    ID gène
    10410
    UniProt
    Q01628
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